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When it comes to vitamin D, most adults exhibit either frank deficiency, which results in clear clinical symptoms, or insufficiency, which often goes undetected. Frailty is a 2001 American psychological horror film directed by and starring Bill Paxton, and co-starring Matthew McConaughey and Powers Boothe.It marks Paxton's directorial debut.The plot focuses on the strange relationship between two young boys and their fanatically religious father, who believes that he has been commanded by God to kill demons disguised as people. All rights reserved. The research builds on previous work that found that long-term insufficient levels of vitamin D resulted in impaired physical performance in young mice. Additional coauthors are from the Veterans Affairs Western New York Healthcare System and the University at Buffalo. The Veterans Affairs Rehabilitation Research and Development, the National Institutes of Health, and the Indian Trail Foundation funded the work. Serial Killer Revived for a Limited Series Reboot, Five Things You Need To Know About Horror Series Helstrom. A growing body of literature suggests that vitamin D is important for other aspects of health, and a number of researchers in the field consider 30 ng/ml as the necessary minimum level, says coauthor Bruce R. Troen, professor of medicine, chief of the division of geriatrics and palliative medicine, and director of the Center for Successful Aging. The investigators measured frailty in mice based on strategies similar to those used for humans, that define frailty as having three or more of the following: unexpected weight loss, weak grip strength, poor endurance, low activity levels, and slow gait speed. The researchers found that frailty progressed in two groups of the mice where daily vitamin D consumption was either 125 International Units (IU) per kilogram of chow, resulting in an insufficient level, or 1,000 IU per kilogram of chow, which establishes serum levels of vitamin D considered sufficient for a human. The NAM Food and Nutrition Board has recommended that adults ages 19–70 consume 600 IU of vitamin D per day and that individuals over 70 consume 800 IU of vitamin D per day. “We found that in aged mice, low levels of vitamin D result in physical declines, such as reduced grip strength and grip endurance—the ability to sustain a grip—and that they started developing as soon as one month after reduction of vitamin D intake,” says first author Kenneth L. Seldeen, research assistant professor in the medicine department in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, “We also found that low vitamin D levels were associated with a decline in both balance and coordination.

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